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SMILES COc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCCNS(=O)(=O)c2cccc(F)c2)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50585069   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 526nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 102nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 111nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 7.98E+3nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of ERN1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 7.58E+3nMAssay Description:Inhibition of NTRK2 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetHomeodomain-interacting protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of HIPK1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 360nMAssay Description:Inhibition of MAPK8 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 95nMAssay Description:Inhibition of MAPK11 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 88nMAssay Description:Inhibition of MAPK14 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of ZAK (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50585069(CHEMBL5081210)copy SMILES
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0SMNPubMed