null

SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 511598   

TargetDNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))TBA
LigandPNGBDBM511598(US11059801, Compound dBET6)copy SMILES
Affinity DataIC50: 134nMAssay Description:A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G44TFMUS Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM511598(US11059801, Compound dBET6)copy SMILES
Affinity DataIC50: 81nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M98MVPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM511598(US11059801, Compound dBET6)copy SMILES
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M98MVPubMed
LigandPNGBDBM511598(US11059801, Compound dBET6)copy SMILES
Affinity DataIC50: 14nMAssay Description:AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G44TFMUS Patent