null

SMILES CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cc2)N2CCN(CC2)C(=O)CN(C)C)ncc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 525753   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM525753(US11174252, Compound 440)copy SMILES
Affinity DataIC50: 2nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27D2Z99US Patent
LigandPNGBDBM525753(US11174252, Compound 440)copy SMILES
Affinity DataIC50: 3.50E+4nMAssay Description:PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27D2Z99US Patent
LigandPNGBDBM525753(US11174252, Compound 440)copy SMILES
Affinity DataIC50: 24nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27D2Z99US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM525753(US11174252, Compound 440)copy SMILES
Affinity DataIC50: 2nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27D2Z99US Patent