null
SMILES CC(C)(N1CCC(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CC1)c1cc(Cl)cc(Cl)c1
InChI Key InChIKey=KWAURGCHFYCYPQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 71064
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 18.2nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 1 hr in presence of veratridine and anthropleurin-C by sodium influx assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 15.8nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 1 hr in presence of veratridine by sodium influx assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair