null

SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1

InChI Key InChIKey=ATXQKLAYIZHIBL-WDZFZDKYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7245   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM7245((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)copy SMILEScopy InChI
Affinity DataIC50: 82nMpH: 7.4 T: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7SW7PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM7245((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7SW7PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM7245((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7SW7PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM7245((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7SW7PubMed