null

SMILES CCCCc1c([nH]c2nccnc12)-c1ccc(OC)cc1

InChI Key InChIKey=WVMANZPBOBRWCB-UHFFFAOYSA-N

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7364   

TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM7364(6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 38 |...)copy SMILEScopy InChI
Affinity DataKi:  933nMAssay Description:Inhibition of human recombinant PYK2 by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212DQPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM7364(6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 38 |...)copy SMILEScopy InChI
Affinity DataKi:  2.63E+3nMAssay Description:Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212DQPubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM7364(6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 38 |...)copy SMILEScopy InChI
Affinity DataIC50: 912nMAssay Description:Inhibitory concentration against Glycogen synthase kinase-3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2SR0PubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Faculte de Medecine et de Pharmacie

LigandPNGBDBM7364(6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 38 |...)copy SMILEScopy InChI
Affinity DataIC50: 920nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474820PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Faculte de Medecine et de Pharmacie

LigandPNGBDBM7364(6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 38 |...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474820PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Faculte de Medecine et de Pharmacie

LigandPNGBDBM7364(6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 38 |...)copy SMILEScopy InChI
Affinity DataIC50: 700nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474820PubMed