null

SMILES CN(c1ccccc1)c1nccc(n1)-c1cnn2ncccc12

InChI Key InChIKey=XYEFJKRTJUALOK-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8127   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8127(N-methyl-N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.99E+4nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
LigandPNGBDBM8127(N-methyl-N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylp...)copy SMILEScopy InChI
Affinity DataIC50: 186nMAssay Description:Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET...More data for this Ligand-Target Pair
LigandPNGBDBM8127(N-methyl-N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylp...)copy SMILEScopy InChI
Affinity DataIC50: 186nMAssay Description:Inhibition of recombinant human N-terminal Hex-tagged DYRK1A (127 to 485 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8127(N-methyl-N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.99E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed