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SMILES Clc1ccc(cc1Cl)-c1ccc(\C=C2/SC(=S)NC2=O)o1

InChI Key InChIKey=VRRGUXZKRFEHEL-SDQBBNPISA-N

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8425   

TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM8425((5Z)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methylid...)copy SMILEScopy InChI
Affinity DataKi:  510nMAssay Description:Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP46X9PubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM8425((5Z)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methylid...)copy SMILEScopy InChI
Affinity DataKi:  630nMAssay Description:Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP46X9PubMed
TargetLethal factor(Bacillus anthracis)
Burnham Institute for Medical Research

LigandPNGBDBM8425((5Z)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methylid...)copy SMILEScopy InChI
Affinity DataIC50: 7.40E+3nMpH: 7.4 T: 2°CAssay Description:Fluorescence peptide cleavage assay was performed in a 96-well plate. Each reaction contained MAPKKide, LF, and the small-molecule inhibitor. The C-t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TM78BQPubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM8425((5Z)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methylid...)copy SMILEScopy InChI
Affinity DataIC50: 980nMAssay Description:Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP46X9PubMed