null

SMILES N#Cc1ccc2cc(ccc2c1)-c1cccnc1

InChI Key InChIKey=BRNSTMOAGOETDI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 8909   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 691nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+4nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 686nMAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human placental CYP19More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B6008PubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 3nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 686nMpH: 7.4 T: 2°CAssay Description:A solution of 6.25 nmol of progesterone (in 5 μl of MeOH) was dissolved in 140 μl of phosphate buffer (0.05 M; pH 7.4; 1 mM MgCl2; 0.1 mM EDTA ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89C75PubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 691nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89C75PubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 691nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent