null

SMILES Cc1ccc2c(N)c3CCCCc3nc2c1

InChI Key InChIKey=XEAIOWJVFCHDRX-UHFFFAOYSA-N

PDB links: 4 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 8985   

TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057D4RPubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GFMPubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against human erythrocyte acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974WJPubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of human recombinant AChE assessed as reduction in cholinesterase activity using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC365GPubMed
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 4.18E+4nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC365GPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))TBA
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC365GPubMed
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 7.83E+3nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC365GPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))TBA
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 9.86E+4nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC365GPubMed
TargetCholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human plasmatic BuChE assessed as reduction in cholinesterase activity by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC365GPubMed