null

SMILES COc1cc(Oc2ccccc2)ccc1-c1nc([C@H]2C[C@@](C)(O)C2)n2ccnc(N)c12

InChI Key InChIKey=PILAMBNAJPBLFA-RWXRFDSASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 98282   

TargetActivated CDC42 kinase 1(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

US Patent
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 119nMAssay Description:AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XD109JUS Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

US Patent
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H996XCPubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

US Patent
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of ACK1 kinase (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H996XCPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

Curated by ChEMBL
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

Curated by ChEMBL
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

US Patent
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of ACK1 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

Curated by ChEMBL
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

Curated by ChEMBL
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

Curated by ChEMBL
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

US Patent
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of ACK1 (unknown origin) by cellular mechanistic assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
OSI Pharmaceuticals, LLC

Curated by ChEMBL
LigandPNGBDBM98282(US8481733, 94)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MQTPubMed