null
SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12
InChI Key InChIKey=DSXXEELGXBCYNQ-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer. 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 3175
Affinity DataIC50: 10nMAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of STK10 (unknown origin) expressed in Sf9 cells assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptorsubstrate.More data for this Ligand-Target Pair
Affinity DataIC50: 656nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
East China University of Science and Technology
East China University of Science and Technology
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:The inhibition assays against RSK2 in vitro were determined by ADP Quest® (DiscoveRx) in 96-well flat-bottom plates according to the manufacturer...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of His-tagged human PKCalpha expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant SIRT2 by radioactive deacetylase assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human SIRT1More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human SIRT1 by radioactive deacetylase assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human SIRT1 by fluorescent deacetylase assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant SIRT2 by fluorescent deacetylase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of His-tagged human GSK3b expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
University of Dundee
Curated by ChEMBL
University of Dundee
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of His-tagged human MSK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged human S6K1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Ernst-Moritz-Arndt-University Greifswald
Curated by ChEMBL
Ernst-Moritz-Arndt-University Greifswald
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human C-terminally His6-tagged Sirt3 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
East China University of Science and Technology
East China University of Science and Technology
Affinity DataIC50: 10nMAssay Description:Inhibition of RSK2 after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavusMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against Chymotrypsinogen from Thermus flavusMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of Wistar rat GSK-3beta using RRAAEELDSRAGS(P)PQL as substrate after 15 mins in presence of [gamma-32P]-ATP by scintillation counting meth...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
University of Florida
Curated by ChEMBL
University of Florida
Curated by ChEMBL
Affinity DataIC50: 9.95E+3nMAssay Description:Inhibition of human COT1 using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase VRK1(Homo sapiens (Human))
University of Florida
Curated by ChEMBL
University of Florida
Curated by ChEMBL
Affinity DataIC50: 743nMAssay Description:Inhibition of human VRK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase VRK2(Homo sapiens (Human))
University of Florida
Curated by ChEMBL
University of Florida
Curated by ChEMBL
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of human VRK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
University of Florida
Curated by ChEMBL
University of Florida
Curated by ChEMBL
Affinity DataIC50: 52.9nMAssay Description:Inhibition of human HPK1 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetHomeodomain-interacting protein kinase 1(Homo sapiens (Human))
University of Florida
Curated by ChEMBL
University of Florida
Curated by ChEMBL
Affinity DataIC50: 621nMAssay Description:Inhibition of human HIPK1 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Products Limited
Roche Products Limited
Affinity DataIC50: 900nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 3175
ITC DataΔG°: -10.5kcal/mole −TΔS°: 0.223kcal/mole ΔH°: -10.7kcal/mole logk: 1.27E+8
pH: 7.5 T: 10.00°C
pH: 7.5 T: 10.00°C