null
SMILES ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
InChI Key InChIKey=NCNRHFGMJRPRSK-MDZDMXLPSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 97 hits for monomerid = 25150
TargetHistone deacetylase 2(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
Affinity DataKi: 1.10nM ΔG°: -12.2kcal/mole IC50: 1.90nMT: 2°CAssay Description:The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Competitive inhibition of HDAC3 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 59nMAssay Description:Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 75nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
Affinity DataKi: 175nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
Affinity DataKi: 380nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 46nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair
Affinity DataIC50: 353nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair
Affinity DataIC50: 9.85E+3nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Affinity DataIC50: 353nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Affinity DataIC50: 9.90E+3nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extracts incubated for 30 mins by fluorescent assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of purified recombinant HDAC1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by automated patch clamp assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of full length recombinant HDAC1 using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of full length recombinant human HDAC2 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumarin by fluor...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of full length recombinant human HDAC6 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumarin by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of His-tagged full length recombinant human HDAC8 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumar...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of C-terminal His/FLAG-tagged full length recombinant human HDAC1 expressed in baculovirus expression system assessed as release of 7-amin...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by automated Q-patch assayMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity towards Alpha-mannosidase from AlmondMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human LTA4H aminopeptidase activity expressed in Escherichia coli BL21 (DE3) pLysS assessed as formation of p-NA from Ala-p...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 9.90nMAssay Description:Inhibition of recombinant human full length HDAC6 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human full length HDAC8 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair