null
SMILES COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
InChI Key InChIKey=YBHILYKTIRIUTE-UHFFFAOYSA-N
PDB links: 18 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 77 hits for monomerid = 50203126
TargetCytochrome P450 1B1(Homo sapiens (Human))
Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center, Québec, Québec, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval,
Curated by ChEMBL
Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center, Québec, Québec, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval,
Curated by ChEMBL
Affinity DataKi: 44nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataKi: 289nMAssay Description:Inhibition of electric eel AChE by enzyme kinetics assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of horse serum BChE by enzyme kinetics assayMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Konkuk University
Curated by ChEMBL
Konkuk University
Curated by ChEMBL
Affinity DataKi: 1.43E+4nMAssay Description:Inhibition of neuraminidase in influenza A virus (A/Puerto Rico/8/1934(H1N1)) pre-incubated for 30 mins before NA-Star substrate addition for 30 mins...More data for this Ligand-Target Pair
Affinity DataKi: 1.30E+5nMAssay Description:Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.
Curated by ChEMBL
TCG Lifesciences Ltd.
Curated by ChEMBL
Affinity DataIC50: 6.61E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BChE using butylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's methodMore data for this Ligand-Target Pair
TargetSentrin-specific protease 8(Homo sapiens (Human))
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
TargetSentrin-specific protease 8(Homo sapiens (Human))
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 770nMpH: 8.0 T: 2°CAssay Description:Briefly, 140 μL of sodium phosphate buffer (pH 8.0), 20 μL of each tested compound with different concentrations (4, 20, and 100 μM) a...More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Chungnam National University
Curated by ChEMBL
Chungnam National University
Curated by ChEMBL
Affinity DataIC50: 3.85E+4nMAssay Description:Inhibition of recombinant Influenza A virus H1N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as subst...More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Chungnam National University
Curated by ChEMBL
Chungnam National University
Curated by ChEMBL
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of Influenza A virus H5N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine as substrate assessed as substrate hydrolysis by spectrophotometric/Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of BChE (unknown origin) using butyrylthiocholine as substrate assessed as substrate hydrolysis by spectrophotometric/Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of horse serum BChE by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE by modified Ellman methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BuChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine BChE after 15 mins by Ellman's method using acetylcholine as substrateMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE after 15 mins by Ellman's method using acetylcholine as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum ButyrylcholinesteraseMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AcetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride substrate as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of AChE assessed as hydrolysis of acetylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of BChE assessed as hydrolysis of butrylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assayMore data for this Ligand-Target Pair
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics
Curated by ChEMBL
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics
Curated by ChEMBL
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of telomeraseMore data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Inhibition of human AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 2.74E+3nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli K12 FtsZ assembly by light-scattering assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant Escherichia coli K12 FtsZ GTPase activity by malachite green sodium molybdate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibition of human recombinant POPMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of electric eel AChE using acetylcholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of equine serum BuChE using butyrylcholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate incubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.
Curated by ChEMBL
TCG Lifesciences Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.58E+4nMAssay Description:Inhibition of SrtAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibition of Staphylococcus aureus ATCC 6538p sortase A expressed in Escherichia coli using dabcyl-QALPETGEE-edans as substrate incubated for 1 hr b...More data for this Ligand-Target Pair
TargetCytochrome P450 1B1(Homo sapiens (Human))
Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center, Québec, Québec, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval,
Curated by ChEMBL
Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center, Québec, Québec, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval,
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.97E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
Affinity DataIC50: 2.97E+5nMAssay Description:Inhibition of Human immunodeficiency virus 1 NL4.3 reverse transcriptase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 3.15E+5nMAssay Description:Inhibition of Sus scrofa (pig) pancreatic lipase type 2 using PNPB as substrate pre-incubated with enzyme for 5 min prior to substrate addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 3.07E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibition of POP (unknown origin)More data for this Ligand-Target Pair