null
SMILES Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
InChI Key InChIKey=GOTYRUGSSMKFNF-UHFFFAOYSA-N
PDB links: 4 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 65454
3D Structure (crystal)Affinity DataKi: 1.49E+3nMAssay Description:Binding affinity to CBRN (unknown origin) incubated for 60 mins by lenalidomide displacement assayMore data for this Ligand-Target Pair
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.63E+4nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
TargetGlyceraldehyde-3-phosphate dehydrogenase, cytosolic(Leishmania mexicana)
Celgene Corporation
US Patent
Celgene Corporation
US Patent
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
TargetGranulocyte-macrophage colony-stimulating factor(Homo sapiens (Human))
Celgene Corporation
US Patent
Celgene Corporation
US Patent
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.19E+3nMAssay Description:Inhibition of BRD4 bromodomain 2 (unknown origin) in HEK293 cells cotransfected with eGFP by flow cytometry based mCherry reporter gene analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.78E+4nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMpH: 7.0Assay Description:The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMpH: 8.0 T: 2°CAssay Description:Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:To measure compound binding to endogenous CRBN.More data for this Ligand-Target Pair