null

SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1

InChI Key InChIKey=VXMYWVMXSWJFCV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50000315   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of cardiac phosphodiesterase-3 isolated from canine heart.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q241708FPubMed
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+5nMAssay Description:Inhibition of fraction II of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1W70PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of cGMP PDE II enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K79P9PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 7.60E+5nMAssay Description:Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58MXTPubMed
TargetPhosphodiesterase(Bos taurus)
Ayerst Laboratories Research, Inc.

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of bovine cardiac phosphodiesterase fraction IIIMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W096GVPubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Guinea Pig cAMP specific phosphodiesterase (PDE III); range 4 to 10More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RN7PubMed
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory concentration against cGMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27S7MS4PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 7.60E+5nMAssay Description:Inhibitory concentration against cAMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27S7MS4PubMed
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory concentration against cGMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27S7MS4PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory concentration against cAMP PDE III enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27S7MS4PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of cGMP PDE II enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K79P9PubMed
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of cAMP PDE I enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K79P9PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of cGMP PDE II enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K79P9PubMed
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition cGMP PDE I enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K79P9PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human blood platelet c-AMP phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ57SKPubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JW8FHPPubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 MMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27083P1PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of low Km cyclic cAMP phosphodiesterase PDE III of guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58MXTPubMed
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58MXTPubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of guinea pig phosphodiesterase type IIIMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B56MZQPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of canine cardiac cAMP phosphodiesterase (cAMP-PDE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1N40PubMed
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+6nMAssay Description:Inhibition of fraction I of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1W70PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of fraction III of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q1W70PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)copy SMILEScopy InChI
Affinity DataIC50: 7.60E+5nMAssay Description:Inhibitory concentration against cAMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27S7MS4PubMed