null

SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C

InChI Key InChIKey=FHQYJZCJRZHINA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50058163   

TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K273GPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K273GPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  1.61nMAssay Description:Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2610ZGPPubMed
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GM85VGPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28S4PPSPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Binding affinity of the compound against [125I]-Try0-o-Corticotropin-releasing Factor to Corticotropin releasing hormone receptor 1 from ovineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1JQPPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Antagonistic activity for Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21V5D5NPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SQ8ZPKPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]-TYR-ovine CRH from cloned human corticotropin releasing factor receptor 1 expressed in 293 EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M64WZPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5VR1PubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4RJ4PubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q269733TPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  3.70nMAssay Description:Binding affinity by displacement of [125I]-Tyr-o-CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cel...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2GJWPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q269733TPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi:  56nMAssay Description:Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2125RTCPubMed
TargetCorticotropin-releasing factor receptor 2(RAT)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1JQPPubMed
TargetCorticotropin-releasing factor receptor 2(RAT)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GM85VGPubMed
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of binding of 70 pM [125I]-Try0-o-Corticotropin-releasing Factor (CFR) to Corticotropin releasing hormone receptor 1 in Rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1JQPPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55PS1PubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Displacement of ovine [125I]CRF from human CRF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z73JBPubMed