null

SMILES COc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

InChI Key InChIKey=QZZMUIJVVAGHJA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50059346   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM50059346(CHEMBL3393354 | US9156845, 97)copy SMILEScopy InChI
Affinity DataIC50: 28nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DB80MWUS Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM50059346(CHEMBL3393354 | US9156845, 97)copy SMILEScopy InChI
Affinity DataIC50: 46nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DB80MWUS Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM50059346(CHEMBL3393354 | US9156845, 97)copy SMILEScopy InChI
Affinity DataIC50: 882nMAssay Description:Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5X2WPubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50059346(CHEMBL3393354 | US9156845, 97)copy SMILEScopy InChI
Affinity DataIC50: 766nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human STK3 (18 to 311 residues) expressed in Escherichia coli using myelin basic protein as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52TH8PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM50059346(CHEMBL3393354 | US9156845, 97)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5X2WPubMed
TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50059346(CHEMBL3393354 | US9156845, 97)copy SMILEScopy InChI
Affinity DataIC50: 836nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human STK4 (43 to 431 residues) expressed in Escherichia coli using myelin basic protein as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52TH8PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM50059346(CHEMBL3393354 | US9156845, 97)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 G2019S mutant using fluorescein-labeled LRRKtide peptide substrate incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5X2WPubMed