null

SMILES NC(=O)C([C@@H]1CCN(CCc2ccc3OCCc3c2)C1)(c1ccccc1)c1ccccc1

InChI Key InChIKey=HXGBXQDTNZMWGS-RUZDIDTESA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50109647   

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  0.740nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor transiently expressed in HEK293T cell membranes incubated for 1 hr by scint...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5XWBPubMedDrugBank
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  0.840nMAssay Description:Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M3More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P26ZVKPubMedDrugBank
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  0.840nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6GX9PubMedDrugBank
TargetMuscarinic acetylcholine receptor M3(RAT)
Creighton University

Curated by PDSP Ki Database
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8J85PubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72J70PubMedDrugBank
TargetMuscarinic acetylcholine receptor M3(RAT)
Creighton University

Curated by PDSP Ki Database
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8J85PubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Banyu Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6GX9PubMedDrugBank
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Banyu Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P26ZVKPubMedDrugBank
TargetMuscarinic acetylcholine receptor M3(RAT)
Creighton University

Curated by PDSP Ki Database
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular glandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2W0FPubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  5.5nMAssay Description:Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P26ZVKPubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  5.5nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6GX9PubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor transiently expressed in HEK293T cell membranes incubated for 1 hr by scint...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5XWBPubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Banyu Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  8.60nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6GX9PubMedDrugBank
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Banyu Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  8.60nMAssay Description:Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P26ZVKPubMedDrugBank
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor transiently expressed in HEK293T cell membranes incubated for 1 hr by scint...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5XWBPubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6GX9PubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  47nMAssay Description:Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P26ZVKPubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Binding affinity to human muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72J70PubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Ranbaxy Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKi:  63nMAssay Description:Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2W0FPubMed
TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J104W7PubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataEC50:  11nMAssay Description:Antagonist activity at muscarinic M3 receptor (unknown origin) expressed in HEK293 cells coexpressing EA tagged beta-arrestin2 assessed as inhibition...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5XWBPubMedDrugBank
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J104W7PubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J104W7PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J104W7PubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataEC50:  32nMAssay Description:Agonist activity at human muscarinic M3 receptor expressed in HEK293 cells assessed as increase in IP1 accumulation incubated for 90 min by TR-HTRF a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5XWBPubMedDrugBank
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataEC50:  45nMAssay Description:Antagonist activity at human muscarinic M3 receptor expressed in HEK293 assessed as inhibition of carbachol-induced IP1 accumulation preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5XWBPubMedDrugBank
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 1.58E+6nMAssay Description:Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J104W7PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J104W7PubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
UCB Pharma

Curated by ChEMBL
LigandPNGBDBM50109647(2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrro...)copy SMILEScopy InChI
Affinity DataKd:  50nMAssay Description:Antagonism in muscarinic M3 receptor in guinea pig left atriaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72J70PubMed