null
SMILES [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
InChI Key InChIKey=OIGNJSKKLXVSLS-VWUMJDOOSA-N
PDB links: 2 PDB IDs match this monomer. 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 143 hits for monomerid = 19190
Affinity DataKi: 0.290nMAssay Description:Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-dexamethasone from human glucocorticoid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-DexamethasoneMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Displacement of radiolabeled dexamethasone from GRMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Displacement of radiolabeled dexamethasone from GRMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
TargetCorticosteroid-binding globulin(Homo sapiens)
Nippon Zoki Pharmaceutical Company Ltd.
Curated by ChEMBL
Nippon Zoki Pharmaceutical Company Ltd.
Curated by ChEMBL
Affinity DataKi: 31nMAssay Description:Binding affinity to human CBG receptor (corticosteroid-binding globulins)More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Binding affinity for mineralocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity at progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.52E+3nMAssay Description:Displacement of [3H]-methyltrienolone from human androgen receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 2.66E+3nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
Affinity DataKi: 2.76E+3nMAssay Description:Binding affinity towards testosterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.76E+3nMAssay Description:Binding affinity for androgen receptorMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity for progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of fluorescently labeled ligand from ERalpha receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]-progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to ERalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]-progesterone.More data for this Ligand-Target Pair
Affinity DataKi: >6.00E+3nMAssay Description:Binding affinity to progesterone receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of fluorescently labeled ligand from progesterone receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-methyltrienolone from human progesterone receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.01E+5nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...More data for this Ligand-Target Pair
Affinity DataIC50: 13.8nM EC50: 4.5nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
Affinity DataIC50: 13.8nM EC50: 4.5nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataIC50: 14.9nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 0.526nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to DexamethasoneChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Agonist activity at GR assessed as NF-kappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cellsChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Displacement of TAMRA-labeled dexamethasone from mineralocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Agonist activity at glucocorticoid receptor in human foreskin fibroblasts assessed as inhibition of IL-1-induced IL-6 production by trans-repression ...More data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 5.70nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
Affinity DataIC50: 13.8nMAssay Description:Inhibition of human glucocorticoid receptor alpha by displacement of [3H]-dexamethasoneMore data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair