null

SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O

InChI Key InChIKey=WOSKHXYHFSIKNG-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50331094   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR2106PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
"Magna Gr£cia" University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataKi:  133nMAssay Description:Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8X7ZPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
"Magna Gr£cia" University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8X7ZPubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
"Magna Gr£cia" University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8X7ZPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD224DPubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD224DPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system using Ulight-JA...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4P4JPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4P4JPubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4P4JPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2443BPubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2443BPubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2443BPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2443BPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
In DepthDetails
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03XZPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.19E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetFerrochelatase, mitochondrial [R115L](Homo sapiens (Human))
Technical University of Munich

LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataKd:  3.10E+3nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB51R8PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)copy SMILEScopy InChI
Affinity DataKd:  2.10nMAssay Description:Binding affinity to VEGFR2 (unknown origin) by proteros reporter displacement assayMore data for this Ligand-Target Pair