null

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(C4CCCC4)c3n2)cc1

InChI Key InChIKey=FUBDWXAVMGEMPP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 6276   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46Q5BPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46Q5BPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Tours

Curated by ChEMBL
LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6DQDPubMed
TargetSerine/threonine-protein kinase PAK 1 [249-545,K299R](Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 483nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27T4SPubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27T4SPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Tours

Curated by ChEMBL
LigandPNGBDBM6276(8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46Q5BPubMed