null
SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])Cc3c([nH]c4cc(OC)ccc34)[C@H](C=C(C)C)N1C2=O
InChI Key InChIKey=DBEYVIGIPJSTOR-FHWLQOOXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 32628
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of ATPase in membrane vesicle from BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Inhibition of BCRP in human MCF7/Topo cells assessed as mitoxantrone accumulation preincubated for 10 mins followed by mitoxantrone addition measured...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 731nMAssay Description:Inhibition of ABCG2 in human MCF7/Topo cells after 2 hrs by Hoechst 33342 microplate assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of ABCG2 overexpressed in human MCF7/Topo cells by flow cytometric-based mitoxantrone efflux assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 321nMAssay Description:Inhibition of human adenosine kinase activityMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 731nMAssay Description:Inhibition of ABCG2 in human MCF7/Topo cells after 2 hrs by Hoechst 33342 staining based fluorescence assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 612nMAssay Description:Inhibition of human DNA polymerase deltaMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 451nMAssay Description:Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of BCRP (unknown origin)More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of ABCG2 in topotecan-cultured human MCF7 cells using Hoechst 33342 as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 412nMAssay Description:Activation of ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substrate measured after 1 hr by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of sulfasalazine-stimulated ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substra...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 790nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy of Sciences
Curated by ChEMBL
Hungarian Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of ABCG2 in human MCF7/Topo cells by Hoechst 33342 assayMore data for this Ligand-Target Pair