null
SMILES CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C
InChI Key InChIKey=DBEPLOCGEIEOCV-WSBQPABSSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 71 hits for monomerid = 50334788
Affinity DataKi: 2nMAssay Description:Apparent inhibition constant towards human Steroid 5-alpha-reductase type 2More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataKi: 6.80nMAssay Description:Inhibition of recombinant Steroid 5-alpha-reductase type I was evaluated as binding affinity (in vitro)More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1/2(Rattus norvegicus)
Chinese Academy of Science
Curated by ChEMBL
Chinese Academy of Science
Curated by ChEMBL
Affinity DataKi: 55nMAssay Description:Ability to inhibit Steroid 5-alpha-reductase in rat using Enzyme kinetics method.More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1/2(Rattus norvegicus)
Chinese Academy of Science
Curated by ChEMBL
Chinese Academy of Science
Curated by ChEMBL
Affinity DataKi: 88nMAssay Description:Ability to inhibit Steroid 5-alpha-reductase in rat using Isotope method [3H]T to [3H]-DHT]More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Apparent inhibition constant towards human Steroid 5-alpha-reductase type IMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
Affinity DataKi: 366nMAssay Description:Inhibitory activity against recombinant Steroid 5-alpha-reductase type I expressed in CHO cellsMore data for this Ligand-Target Pair
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataKi: 1.10E+4nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:This work was performed at the MDS Pharma Services, Pharmacology Laboratories, Taiwan. The assay was an in vitro evaluation of the ability of an extr...More data for this Ligand-Target Pair
Affinity DataIC50: 630nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:The activity of the isozyme 5α-R type 2 was assayed as previously described [Hirosumi et al., J. Steroid Biochem. Mol. Biol., 52:357-363; Bratoe...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against 5-alpha Reductase-2 on human prostate homogenates from surgically derived benign hyperplastic tissueMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.30E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.30E+5nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human prostate type 2 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human 5alpha-2 reductase expressed in HEK293 cells assessed as suppression of conversion of [3]androstenedione incubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 453nMAssay Description:Inhibition of human 5alpha-1 reductase expressed in HEK293 cells assessed as suppression of conversion of [3]androstenedione incubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as formation dihydrotestosterone from [4-14C] testosteroneMore data for this Ligand-Target Pair
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase(Mycobacterium tuberculosis)
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataIC50: 3.12E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis 3 beta hydroxysteriod dehydrogenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 147nMAssay Description:Inhibition of rat 5-alpha-reductase type 2 by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataIC50: 911nMAssay Description:Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2 receptor from human prostate homogenatesMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Compound was tested for the inhibitory activity against Steroid 5-alpha-reductase type 1 in ratMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1/2(Rattus norvegicus)
Chinese Academy of Science
Curated by ChEMBL
Chinese Academy of Science
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH).More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Compound was tested for inhibition of Type I 5-alpha-reductase in Human genital skin (Hs68) foreskin fibroblast cells.More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type 2 in SW-13-transfected cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 218nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against human 5-alpha Reductase-1 expressed in DU-145 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibitory activity was measured on rat Steroid 5-alpha-reductase type 2More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Binding affinity to recombinant human Steroid 5-alpha-reductase type I was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibitory activity measured on human steroid 5-alpha-reductase type 2More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human Steroid 5-alpha-reductase type IMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:In vitro inhibitory activity against human type 1 5-alpha reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:In vitro inhibitory activity against human type 2 5-alpha reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of type 1 steroid-5-alpha-reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Compound was tested in vitro for inhibitory activity against type 2 5-alpha reductase Isozyme homogenated from rat epididymisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibitory activity against steroid 5-alpha-reductase type 2 in human prostate homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type I expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type II expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:In vitro inhibitory activity against Steroid 5-alpha-reductase type I of human DU 145 prostatic tumor cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of Steroid 5-alpha-reductase type 2 from human benign prostatic hyperplasia (BPH) tissueMore data for this Ligand-Target Pair