null
SMILES CN1CCN(CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1
InChI Key InChIKey=RHJLQMVZXQKJKB-JDXGNMNLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 50229129
Affinity DataKi: 0.200nMAssay Description:Time dependent inhibition of Trypanosoma cruzi cruzain using Cbz-Phe-Arg-AMC as substrate assessed as inhibition constant for EI complex measured for...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataKi: 20nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 15 to 30 mins by fluores...More data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Irreversible inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataKi: 220nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
Affinity DataKi: 220nMAssay Description:Irreversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Irreversible inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
Affinity DataKi: 390nMAssay Description:Irreversible inhibition of human cathepsin BMore data for this Ligand-Target Pair
Affinity DataKi: 390nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 81nMAssay Description:Inhibition of papaya papain assessed as reduction in p-nitoaniline release using Nalpha-benzoyl-L-arginine 4-nitroanilide hydrochloride as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human Cathepsin B using Cbz-Phe-Arg-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in Escherichia coli using Cbz-Phe-Arg-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-AMC as substrate by spectrofluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Cbz-Phe-Arg-AMC as substrate and measured up to 40 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of rhodesainMore data for this Ligand-Target Pair
TargetCathepsin B-like cysteine protease(Trypanosoma brucei)
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Trypanosoma brucei Cathepsin B-like protease after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain by fluorescence techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Trypanosoma cruzi recombinant cruzain by fluorescence techniqueMore data for this Ligand-Target Pair