null

SMILES CC(=O)C(C#N)C(=O)Nc1cc(Br)ccc1Br

InChI Key InChIKey=BQLDGDMKDYAGNE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 24941   

TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataKi:  7.20E+3nM ΔG°:  -6.94kcal/mole IC50: 6.10E+4nMpH: 7.0 T: 2°CAssay Description:The mode of human PLK3 inhibition by LFM-A13 was examined in titration experiments using increasing concentrations of [gamma-32P]ATP and purified N-t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetHomoserine kinase(Escherichia coli)
McMaster University

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataKi:  1.20E+4nM ΔG°:  -6.98kcal/molepH: 7.5 T: 2°CAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GWVPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 2.67E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 2.81E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche Inc.

Curated by ChEMBL
LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant BTK expressed in baculovirus expression vector systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KMFPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 2.15E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche Inc.

Curated by ChEMBL
LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of human BTKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82RHPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche Inc.

Curated by ChEMBL
LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant BTKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82RHPubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of Plk3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82RHPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche Inc.

Curated by ChEMBL
LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046C4PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetSerine/threonine-protein kinase PLK1(Xenopus laevis)
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Purified Plx1 was first incubated with different concentrations of LFM-A13. The substrate, GST-Cdc25 peptide (254-316) and [gamma-32P]ATP were added ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Paradigm Pharmaceuticals

LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MCRPubMed