null

SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1

InChI Key InChIKey=QHADVLVFMKEIIP-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50172078   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length AXL after 4 hrs followed by stimulation with human recombinant Gas6 for 15 minutes by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M96FSPubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human full length AXL by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M96FSPubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of RON (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z986GPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of cMET (unknown origin) by FISH assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*STAR

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27084T7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
A*STAR

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 109nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27084T7PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
A*STAR

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z777ZPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCytochrome P450 2C19(Homo sapiens (Human))TBA
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*STAR

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z777ZPubMed