null

SMILES NCCNC(=O)c1ccc(Cl)cn1

InChI Key InChIKey=JZXRLKWWVNUZRB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50029816   

TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataKi:  3.90nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38V8KPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Ample...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44V06PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataKi:  72nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38V8KPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataKi:  84nMAssay Description:Inhibition constant against human recombinant Monoamine oxidase-B More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5FKRPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))TBA
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Ample...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44V06PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of human recombinant MAO-B assessed as kynuramine oxidation to 4-hydroxyquinoline formation by spectrofluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32XDJPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataEC50:  7.10E+3nMAssay Description:Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38V8KPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataKd:  66nMAssay Description:Binding affinity to human recombinant microsomal MAO-B by ITCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38V8KPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BT1 cells microsome fraction by fluorescence spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7QM4PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human MAO-B after 20 mins using 50 uM kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154JWFPubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7HST
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:In vitro inhibitory activity against monoamine oxidase B (MAO-B) in rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7HST
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of human recombinant MAO-B expressed in insect cell microsome assessed as 4-hydroxyquinoline formation using kynuramine as substrate after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ2C4WPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67K5KPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WCTPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by flu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2KM1PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3P2RPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate after 20 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9KQPPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC06JKPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of human recombinant MAO-B expressed in insect cells microsomes assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NBTPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human MAOB expressed in insect cell microsomes using kynuramine as substrate measured after 20 mins by fluorescence spectro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VD72QDPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of human recombinant monoamine oxidase-B assessed as kynuramine conversion to 6-hydroxyquinoline after 20 mins by fluorescence spectrophot...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ42TMPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Reversible inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4MB3PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N5DPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7MBXPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of human recombinant MAOB using kynuramine substrate assessed as reduction in MAO-generated 4-hydroxyquinoline level by fluorescence spect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC3429PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human MAO-B expressed in insect cells assessed as inhibition of oxidation of kynuramine to 4-hydroxyquinoline after 20 mins...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90B7KPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate assessed as 4-hydroxyquinoline production after 30 mins by fluorescence spectroph...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K93936PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
In DepthDetails
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity against rat brain Monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T72GFVPubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against rat brain Monoamine oxidase BMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T72GFVPubMed