null

SMILES CC(C)(C)[C@@H]1NC(=O)OCC(C)(C)CCCCc2cccc3CN(Cc23)C(=O)O[C@@H]2C[C@H](N(C2)C1=O)C(=O)N[C@@]1(C[C@H]1C=C)C(=O)NS(=O)(=O)C1CC1

InChI Key InChIKey=HPAPGONEMPZXMM-ONAXAZCASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50326055   

TargetGenome polyprotein(Hepatitis C virus)
TBA

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataKi:  0.0500nMAssay Description:Inhibition of HCV genotype 1a NS3/4A protease using Ac-DED(Edans)EEAbu-psi[COO]ASK(Dabcyl)-NH2 as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GX4D50PubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataKi:  22nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0R6VPubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataKi:  77nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease D168V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0R6VPubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataKi:  88nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0R6VPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Neutrophil elastase 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human Cathepsin BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human Cathepsin LMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetCathepsin F(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Trypsin activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z3213VPubMed
TargetPlasminogen(Homo sapiens (Human))
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human plasminMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z3213VPubMed
TargetChymotrypsin-like elastase family member 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Pancreatic elastase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetChymase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ChymaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetCathepsin L2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cathepsin VMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8F39PubMed