null

SMILES [H][C@]1(O)C[C@@]([H])(C[C@@]1([H])COS(N)(=O)=O)n1ccc2c(N[C@@]3([H])CCc4ccccc34)ncnc12

InChI Key InChIKey=MPUQHZXIXSTTDU-QXGSTGNESA-N

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50285607   

TargetNEDD8-activating enzyme E1 catalytic/regulatory subunit(Homo sapiens)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP84PFPubMed
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1HQKPubMed
TargetUbiquitin-like modifier-activating enzyme ATG7(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ATG7 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542R5NPubMed
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of UBA6 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542R5NPubMed
TargetNEDD8(Homo sapiens)
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of NEDD8 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542R5NPubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant His-tagged NAE1 expressed in baculovirus expression system after 90 mins in presence of FLAG-tagged NEDD8 by TR-FRET ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4DVZPubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))TBA
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN99CFPubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C21WJPubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 8.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C21WJPubMed
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C21WJPubMed
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C21WJPubMed
TargetUbiquitin-like modifier-activating enzyme ATG7(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C21WJPubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1HQKPubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1HQKPubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataEC50:  30nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1HQKPubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SAE (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542R5NPubMed