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SMILES [#6]-[#7](-[#6])-[#6](=[#7])\[#7]=[#6](\[#7])-[#7]

InChI Key InChIKey=XZWYZXLIPXDOLR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50229665   

TargetDihydrofolate reductase(Homo sapiens (Human))
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataKi:  1.80E+7nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72N1JPubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+6nMAssay Description:TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T154ZHPubMed
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 2.01E+6nMAssay Description:TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T154ZHPubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76DWZPubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q20JNPubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP488MPubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6BX8PubMed
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)copy SMILEScopy InChI
Affinity DataIC50: 1.23E+6nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9MHQPubMed