null
SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
InChI Key InChIKey=DQCKKXVULJGBQN-XFWGSAIBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 50000787
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 0.0420nMAssay Description:Antagonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of compound 16-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetMu-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 0.460nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 0.646nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 0.810nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 1.07nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in rat brain homogenate after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by SPAMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 3.60nMAssay Description:Antagonist activity at mu opioid receptor expressed in HEK293 cells assessed as inhibition of compound 11-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by SPAMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 11nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in rat brain homogenate after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by SPAMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: 67nMAssay Description:Antagonist activity at delta opioid receptor expressed in HEK293 cells assessed as inhibition of compound 14-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Human BioMolecular Research Institute
Curated by ChEMBL
Human BioMolecular Research Institute
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inverse agonist activity at NOP expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetNorepinephrine transporter(RAT)
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R.W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University of Maryland
Curated by ChEMBL
University of Maryland
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in cultured hippocampal neuronsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Maryland
Curated by ChEMBL
University of Maryland
Curated by ChEMBL
Affinity DataIC50: 1.41E+5nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in CA1 stratum radiatum interneuronsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Maryland
Curated by ChEMBL
University of Maryland
Curated by ChEMBL
Affinity DataIC50: 1.39E+5nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in CA1 stratum radiatum interneuronsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University of Maryland
Curated by ChEMBL
University of Maryland
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha7 noncompetitively in cultured hippocampal neuronsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Maryland
Curated by ChEMBL
University of Maryland
Curated by ChEMBL
Affinity DataIC50: 3.10E+4nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in acute hippocampal slicesMore data for this Ligand-Target Pair