null
SMILES [#6]-[#8]-[#6@@H]1-[#6@@H](-[#8]-[#6](-[#7])=O)-[#6@@H](-[#8])-[#6@H](-[#8]-c2ccc3c(-[#8])c(-[#7]-[#6](=O)-c4ccc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6])c4)c(=O)oc3c2-[#6])-[#8]C1([#6])[#6]
InChI Key InChIKey=YJQPYGGHQPGBLI-KGSXXDOSSA-N
PDB links: 13 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 73 hits for monomerid = 50226181
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Inhibition of Escherichia coli H560 DNA gyrase B ATPase activity after 30 mins by ammonium molybdate/malachite green-based phosphate detection assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.80E+3nMAssay Description:Displacement of sGFP-p62-LIR peptide from human N-terminal SNAP-fused LC3A by time-resolved FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.93E+4nMAssay Description:Displacement of sGFP-p62-LIR peptide from human N-terminal SNAP-fused LC3B by time-resolved FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.67E+5nMAssay Description:Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Mycobacterium tuberculosis gyrase supercoiling, relaxation, and decatenation assays were carried out as described previously.More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pNO1 plasmid and biotinylated oligonucelotide incubated for 30 mins by fluorescence base...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed pNO1 plasmid and biotinylated oligonucelotide incubated for 30 mins by fluorescence based DNA...More data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
University of Ljubljana
Curated by ChEMBL
University of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 using relaxed pNO1 plasmid and biotinylated oligonucelotide incubated for 30 mins by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed pBR322 DNA as substrate after 3 hrs by DNA super-coiling assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pBR322 DNA as substrate after 3 hrs by DNA super-coiling assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
University of Ljubljana
Curated by ChEMBL
University of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 using kinetoplast DNA as substrate by decatenation assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Institute of Technology& Science-Pilani
Curated by ChEMBL
Institute of Technology& Science-Pilani
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of 6-His-tagged Mycobacterium smegmatis GyrB expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 100 mins in presence of AT...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Institute of Technology& Science-Pilani
Curated by ChEMBL
Institute of Technology& Science-Pilani
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduction in ATPase activity incu...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as supercoiling of relaxed pBR322 plasmid after 45 mins by ethidium bromide staining based ag...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as supercoiling of relaxed pNO1 plasmid after 30 mins by SybrGOLD staining based fluorescence...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of HSP90 dependent refolding of heat denatured firefly luciferase in rabbit reticulocyte lysate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence of b...More data for this Ligand-Target Pair
Affinity DataIC50: 408nMAssay Description:Inhibitory activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Institute of Technology& Science-Pilani
Curated by ChEMBL
Institute of Technology& Science-Pilani
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of Mycobacterium smegmatis 155 6His-tagged DNA gyrase B catalytic domain ATPase activity expressed in Escherichia coli BL21 (DE3) pLysS ce...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hospital for Sick Children
Curated by ChEMBL
Hospital for Sick Children
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:TP_TRANSPORTER: inhibition of mitoxantrone efflux in BCRP-expressing MCF7-MX cellsMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataKd: 7nMAssay Description:Binding affinity to Escherichia coli H560 DNA gyrase BMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Institute of Technology& Science-Pilani
Curated by ChEMBL
Institute of Technology& Science-Pilani
Curated by ChEMBL
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B expressed in BL21(DE3)pLysS cells assessed as inhibition of DNA supercoiling activity in presence ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Dainippon Pharmaceutical Co., Ltd
Curated by ChEMBL
Dainippon Pharmaceutical Co., Ltd
Curated by ChEMBL
Affinity DataIC50: 6.52E+5nMAssay Description:Inhibitory activity against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Affinity DataIC50: 408nMAssay Description:Inhibitory activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase A/DNA gyrase B supercoiling activity using relaxed pNO1 DNA as substrate after 30 mins in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of Staphylococcus aureus N-terminal His6-tagged DNA gyrase subunit GyrA/GyrB supercoiling activity expressed in Escherichia coli BL21 (DE3...More data for this Ligand-Target Pair
Affinity DataIC50: 2.56E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-alphaMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA gyrase B using relaxed pNO1 DNA as substrate incubated for 30 mins and measured by sybrGOLD staining ba...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B using relaxed pNO1 DNA as substrate incubated for 30 mins and measured by sybrGOLD staining based fl...More data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATPase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase-mediated supercoiling of relaxed DNA using pBR 322 as substrate by agarose gel electrophoresis analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B preincubated for 10 mins followed by ATP addition measured after 30 mins by purine nucleoside phosph...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli C-terminal His6-tagged DNA gyrase B expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by ATP a...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase activityMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase ATPase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 408nMAssay Description:Iinhibitory activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of supercoiling activity using relaxed pBR322 plasmid as substrate after 3...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
Affinity DataIC50: 457nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
Affinity DataIC50: 408nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetNonstructural protein 3(Zika virus)
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 2.44E+4nMAssay Description:Inhibition of NS2B-NS3 protease in Zika virus Puerto Rico/PRVABC5 infected in human Huh7 cells assessed as antiviral activity measured 48 hrs post in...More data for this Ligand-Target Pair
TargetNonstructural protein 3(Zika virus)
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 2.44E+4nMAssay Description:Inhibition of NS2B-NS3 protease in Zika virus Puerto Rico/PRVABC5 assessed as antiviral activity measured 48 hrs post infection by plaque reduction a...More data for this Ligand-Target Pair
TargetNonstructural protein 3(Zika virus)
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 2.44E+4nMAssay Description:Inhibition of NS2B-NS3 protease in Zika virus Puerto Rico/PRVABC5 infected in African green monkey Vero cells assessed as antiviral activity measured...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
The University of Notre Dame
Curated by ChEMBL
The University of Notre Dame
Curated by ChEMBL
Affinity DataEC50: 7.00E+5nMAssay Description:Inhibition of HSP90 at C-terminus (unknown origin)More data for this Ligand-Target Pair
TargetNonstructural protein 3(Zika virus)
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
TargetNonstructural protein 3(Zika virus)
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 2.48E+4nMAssay Description:Inhibition of Zika virus NS2B-NS3 protease by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 168nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair