null

SMILES CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N

InChI Key InChIKey=FWIVDMJALNEADT-SFTDATJTSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50255753   

TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataKi:  0.180nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP55ZMPubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade de S£o Paulo

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataKi:  126nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P34WRPubMed
TargetProcathepsin L(Homo sapiens (Human))
Universidade de S£o Paulo

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of Cathepsin L (unknown origin) using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P34WRPubMed
TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89CQFPubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 183nMAssay Description:Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833T5FPubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetProcathepsin L(Homo sapiens (Human))
Universidade de S£o Paulo

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin F(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 795nMAssay Description:Inhibition of cathepsin FMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin HMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetProcathepsin L(Homo sapiens (Human))
Universidade de S£o Paulo

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of cathepsin L in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of cathepsin B in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin L2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 762nMAssay Description:Inhibition of cathepsin VMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of cathepsin S in human ramos cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin ZMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9BM2PubMed
TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7F6PPubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 500nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7F6PPubMed
TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6QPFPubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7F6PPubMed
TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5DVMPubMed
TargetCathepsin K(Homo sapiens (Human))
CNRS UPR 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2V75PubMed