null

SMILES CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1

InChI Key InChIKey=HESLKTSGTIBHJU-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50269948   

TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human A431 cells by ELISAMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human SKOV3 cells after 60 mins by western blot analysisMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human L3.6pl cells after 60 mins by western blot analysisMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human FG cells after 60 mins by western blot analysisMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Pyk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GQHPubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 486nMAssay Description:Inhibition of human CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GQHPubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 197nMAssay Description:Inhibition of human CDK7/cyclinH/MAT1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GQHPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GQHPubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N30084US Patent
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant FAK (410 to 689 residues) (unknown origin) using Poly (4:1 Glu, Tyr) peptide as substrate enzyme pretreated with substrate ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24F1TTDUS Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5K8CPubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Pyk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5K8CPubMed
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK7/cyclinH/MAT1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5K8CPubMed
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5K8CPubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-FAK domain (410-689) (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataKd:  1.40E+3nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DJ5KHHPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataKd:  72nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4TSSPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q251433MPubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human PC3 cells after 60 mins by western blot analysisMore data for this Ligand-Target Pair