null
SMILES CN[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23
InChI Key InChIKey=RKZSNTNMEFVBDT-MRVPVSSYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 50056443
Affinity DataKi: 9nMAssay Description:Binding affinity towards Dopamine receptor D2 by displacement of [3H]-U-86,170.More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 73nMAssay Description:Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT.More data for this Ligand-Target Pair
Affinity DataKi: 81nMAssay Description:Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 546nMAssay Description:Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 573nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 784nMAssay Description:Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 2.33E+3nMAssay Description:Binding affinity towards Dopamine receptor D3 by displacement of [3H]-(+)-7-OH-DPAT.More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 6.33E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 6.33E+3nMAssay Description:Binding affinity to bovine serum albumin by circular dichroic probe techniqueMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataKi: 1.63E+4nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 1.63E+4nMAssay Description:Binding affinity to bovine serum albumin by circular dichroic probe techniqueMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataEC50: 35nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10.8nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 543nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D2 (short) stably expressed in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
Affinity DataEC50: 4.60nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHO cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]th...More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 669nMAssay Description:Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
Affinity DataEC50: 165nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 501nMAssay Description:Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed...More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 65nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 186nMAssay Description:Agonist activity at human D3 receptor transfected in HEK293T cells by BRET based G0 activation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Compound was evaluated for its binding affinity against Toxoplasma gondii purine nucleoside phosphorylase from cystic strain ME 49 (value indicates c...More data for this Ligand-Target Pair