null
SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(O)=O
InChI Key InChIKey=FAXGPCHRFPCXOO-LXTPJMTPSA-N
PDB links: 9 PDB IDs match this monomer. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 93 hits for monomerid = 912
Affinity DataKi: 0nMAssay Description:Compound was measured for the inhibition of pepsin hydrolysis of hemoglobin.More data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Binding affinity against human cathepsin DChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Inhibition of porcine pepsinMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
CIBA-GEIGY Corporation
Curated by ChEMBL
CIBA-GEIGY Corporation
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity to HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of HIV-1 recombinant protease using DABCYL-GABA-Ser-Asn-Tyr-Pro-Ile-Val-Gln-EDANS as substrate incubated for 30 mins prior to substrate ad...More data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibition of HIV1 protease by Lineweaver-Burke methodMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibition of HIV1 protease by Hanes methodMore data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Inhibition of HIV1 protease by Dixon methodMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Inhibition of HIV-1 recombinant protease using DABCYL-GABA-Ser-Asn-Tyr-Pro-Ile-Val-Gln-EDANS as substrate incubated for 30 mins prior to substrate ad...More data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Inhibition of HIV-1 recombinant protease using DABCYL-GABA-Ser-Asn-Tyr-Pro-Ile-Val-Gln-EDANS as substrate incubated for 30 mins prior to substrate ad...More data for this Ligand-Target Pair
Affinity DataKi: 94nMAssay Description:Inhibition of wild-type HIV-1 protease using fluorogenic peptide substrate incubated for 30 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Antihypertensive activity against human reninMore data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Inhibition of multidrug resistant HIV-1 protease L10I/L63P/A71V/G73S/I84V/L90M mutant using fluorogenic peptide substrate incubated for 30 mins prior...More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
CIBA-GEIGY Corporation
Curated by ChEMBL
CIBA-GEIGY Corporation
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:The compound was tested for its affinity against HIV-1 protease; range 400-1400 nMMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals, Inc.
Agouron Pharmaceuticals, Inc.
Affinity DataKi: 3.10E+3nM ΔG°: -7.81kcal/molepH: 5.5 T: 2°CAssay Description:Protease activity was measured by continuous chromogenic assay. The chromogenic peptide His-Lys-Ala-Arg-Val-Leu- (p-NO2-Phe)-Glu-Ala-Nleu-Ser (Bache...More data for this Ligand-Target Pair
Affinity DataKi: 1.30E+4nMAssay Description:Inhibition of ReninMore data for this Ligand-Target Pair
TargetGag-Pro polyprotein(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
Kyoto Pharmaceutical University
Curated by ChEMBL
Kyoto Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 1.46E+4nMAssay Description:Inhibitory binding affinity towards recombinant human T-cell leukemia virus type I (HTLV-1) proteaseMore data for this Ligand-Target Pair
TargetGag-Pro polyprotein(Human T-cell leukemia virus 1 (strain Japan ATK-1 ...)
Kyoto Pharmaceutical University
Curated by ChEMBL
Kyoto Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 3.65E+4nMAssay Description:Inhibitory binding affinity towards synthesized human T-cell leukemia virus type I (HTLV-1) proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
SIMPSON BIOTECH CO., LTD.
US Patent
SIMPSON BIOTECH CO., LTD.
US Patent
Affinity DataIC50: 500nMAssay Description:In addition, the dipeptidyl peptidase-IV (DPPIV) assay herein was applied to investigate the DPPIV inhibitory activity of the prepared compounds as d...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against human liver Cathepsin D using Cathepsin D assay.More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Compound was measured for the inhibition of pepsin hydrolysis of hemoglobin.More data for this Ligand-Target Pair
Affinity DataIC50: 2.93E+4nMAssay Description:Inhibitory activity against human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Plasma renin inhibitory activity was evaluated in lyophilized human plasma with 0.1%EDTAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of porcine pepsinMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:In vitro inhibitory activity against man (human) plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+3nMAssay Description:In vitro inhibitory activity against rat plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Compound was evaluated for the ability to inhibit human plasma renin.More data for this Ligand-Target Pair
Affinity DataIC50: 0.173nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of cathepsin E in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of cathepsin D in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.181nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human recombinant cathepsin E using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of hog man plasma renin activityMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibitory activity against dog plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMpH: 6.0Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 2.0Assay Description:Inhibitory activity was evaluated against pepsin using porcine pepsin (sigma), porcine hemoglobin (sigma) and 0.02 M KCl-HCl buffer (pH 2)More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibitory activity was evaluated against bovine cathepsin D (sigma)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Compound was tested for inhibition of porcine pepsinMore data for this Ligand-Target Pair