null
SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
InChI Key InChIKey=IOUVKUPGCMBWBT-QNDFHXLGSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 54 hits for monomerid = 20875
Affinity DataKi: 19nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
TargetSolute carrier family 28 member 3(Homo sapiens (Human))
University of Tennessee Health Sciences Center
Curated by ChEMBL
University of Tennessee Health Sciences Center
Curated by ChEMBL
Affinity DataKi: 1.60E+4nMAssay Description:Binding affinity to human recombinant CNT3 expressed in pig PK15NTD cells assessed as [3H]uridine uptake by beta-scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 6.43E+4nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinaseMore data for this Ligand-Target Pair
TargetEquilibrative nucleoside transporter 1(Homo sapiens (Human))
University of Tennessee Health Sciences Center
Curated by ChEMBL
University of Tennessee Health Sciences Center
Curated by ChEMBL
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity to human ENT1 assessed as [3H]uridine uptake by flow cytometryMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 752nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranosideMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Inhibition of human SGLT2 expressed in Xenopus oocyte assessed as [14C]-alpha-methyl glucopyranoside uptakeMore data for this Ligand-Target Pair
TargetSodium/nucleoside cotransporter 1(Homo sapiens (Human))
University of Tennessee Health Sciences Center
Curated by ChEMBL
University of Tennessee Health Sciences Center
Curated by ChEMBL
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human CNT1More data for this Ligand-Target Pair
TargetSodium/nucleoside cotransporter 2(Homo sapiens (Human))
University of Tennessee Health Sciences Center
Curated by ChEMBL
University of Tennessee Health Sciences Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CNT2More data for this Ligand-Target Pair
Affinity DataEC50: 123nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 153nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT2 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 246nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of glucose uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of glucose uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Rattus norvegicus)
Kissei Pharmaceutical Company
Curated by ChEMBL
Kissei Pharmaceutical Company
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Rattus norvegicus)
Kissei Pharmaceutical Company
Curated by ChEMBL
Kissei Pharmaceutical Company
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 536nMAssay Description:Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 185nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 16.4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of SGLT1 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of SGLT2 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 120nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 77nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
Affinity DataEC50: 108nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 197nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 499nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Sus scrofa (Pig))
Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea.
Curated by ChEMBL
Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea.
Curated by ChEMBL
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate pretreated for 15 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataEC50: 240nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Transcriptional activation in CV-1 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Sus scrofa (Pig))
Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea.
Curated by ChEMBL
Department of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of Korea.
Curated by ChEMBL
Affinity DataIC50: 6.82E+4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate pretreated for 15 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human SGLT2 expressed in Xenopus oocytes assessed as reduction in [14C]AMG uptake after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Max-Planck-Institut f£r molekulare Physiologie
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinaseMore data for this Ligand-Target Pair
TargetSodium/nucleoside cotransporter 2(Homo sapiens (Human))
University of Tennessee Health Sciences Center
Curated by ChEMBL
University of Tennessee Health Sciences Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human CNT2 expressed in COS7 cells assessed as reduction in sodium-dependent [14C]-inosine uptake in presence of Na+ by liquid scintill...More data for this Ligand-Target Pair