null

SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC

InChI Key InChIKey=PDMUULPVBYQBBK-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50010981   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(RAT)
University of Tennessee

Curated by PDSP Ki Database
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataKi:  189nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B5XQGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxo Wellcome Research

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataKi:  1.93E+3nMAssay Description:Inhibition of human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ079XPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(RAT)
University of Tennessee

Curated by PDSP Ki Database
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B5XQGPubMed
TargetTumor necrosis factor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:TNF-alpha production in PBMC by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1Q46PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+5nMAssay Description:Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of human lungMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58MXTPubMed
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Activity at Histamine H2 receptor using functional H2 receptor assay on guinea pig atriumMore data for this Ligand-Target Pair
In DepthDetails
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Centre de Neurochimie du CNRS

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21G0NFFPubMed
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human lungMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58MXTPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of cAMP-specific calcium-independent phosphodiesterase (IPDE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9MG8PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibitory activity against Phosphodiesterase 3 from heart.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K93B7DPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Centre de Neurochimie du CNRS

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibitory activity against Phosphodiesterase 4 from heart.More data for this Ligand-Target Pair
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibitory activity against PDE1 from cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K93B7DPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Centre de Neurochimie du CNRS

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DN441HPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataEC50:  3.30E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 9.40E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DN441HPubMed