null

SMILES C#CCN[C@@H]1CCc2ccccc12

InChI Key InChIKey=RUOKEQAAGRXIBM-GFCCVEGCSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 130 hits for monomerid = 10989   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))TBA
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC86K7PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  7.60nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38V8KPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38V8KPubMed
TargetAmine oxidase [flavin-containing] B [I199F](Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  500nMAssay Description:MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2SP5PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  700nM ΔG°:  -8.39kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T151WCPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  700nMAssay Description:Inhibition constant against human recombinant Monoamine oxidase-B More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5FKRPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  700nM ΔG°:  -8.39kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P8494MPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  9.70E+3nM ΔG°:  -6.83kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P8494MPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  9.70E+3nM ΔG°:  -6.83kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T151WCPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:MAO-A and MAO-B activity was measured using radioactive substrates. The substrate for MAO-A was 5 HT and for MAO-B was PEA. When measuring the activi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20Z722NUS Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:MAO-A and MAO-B activity was measured using radioactive substrates. The substrate for MAO-A was 5 HT and for MAO-B was PEA. When measuring the activi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20Z722NUS Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 44nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B (5 mg/mL) were purchased from Sigma-Aldrich, pre-aliquoted and stored at -80 °C. Solutions of test compounds we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X9295TPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 710nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B (5 mg/mL) were purchased from Sigma-Aldrich, pre-aliquoted and stored at -80 °C. Solutions of test compounds we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X9295TPubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of rat brain MAO-B using [14C]-phenylethylamine substrate after 20 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2R0DPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human brain MAO-B using [14C]-phenylethylamine substrate after 20 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2R0DPubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 412nMAssay Description:Inhibition of rat brain MAO-A using [14C]-5- hydroxytryptamine creatinine disulphate substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2R0DPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 710nMAssay Description:Inhibition of human brain MAO-A using [14C]-5- hydroxytryptamine creatinine disulphate substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2R0DPubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of rat brain MAO-B in nuclei-free homogenates using [14C]phenylacetaldehyde substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V989R3PubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V989R3PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human recombinant MAO-A using kynuramine as substrate after 30 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N8316PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine as substrate after 30 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N8316PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of MAOBMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B039WPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of MAOAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B039WPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant MAOB assessed as H2O2 production by Amplex Red reagent-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z962VPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant MAOA assessed as H2O2 production by Amplex Red reagent-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z962VPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant MAO-B expressed in insect cells assessed as kynuramine hydrobromide oxidation after 20 mins by spectrophotometric ana...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95XNPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1ZVWPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human recombinant MAO-A using kynuramine as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1ZVWPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human MAO-B using p-tyramine as substrate assessed as decrease in H2O2 production incubated for 15 mins by fluorimetric met...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1854PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 5.07E+4nMAssay Description:Inhibition of recombinant human MAO-A using p-tyramine as substrate assessed as decrease in H2O2 production incubated for 15 mins by fluorimetric met...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1854PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected High 5 insect cells using kynuramine as substrate incubated for 30 mins by sp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7XZSPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected High 5 insect cells using kynuramine as substrate incubated for 30 mins by sp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7XZSPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81GBJPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 2.61E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81GBJPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4SW1PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4SW1PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 710nMAssay Description:Irreversible inhibition of human cerebral cortex MAO-A using [14C]-5-hydroxytryptamine creatinine disulphate as substrate pretreated for 60 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076J6PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Irreversible inhibition of human cerebral cortex MAO-B using [14C]-phenylethylamin as substrate pretreated for 60 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076J6PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 710nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2CX6PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2CX6PubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China. Electronic address: sangzhipei@126.com.

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6F9FPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6F9FPubMed
TargetCholinesterase(Homo sapiens (Human))
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China. Electronic address: sangzhipei@126.com.

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 4.76E+3nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine chloride as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6F9FPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6F9FPubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 7.47E+3nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate pretreated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2RH4PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 4.97E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using p-tyramine as substrate pretreated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2RH4PubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of human recombinant microsomal MAOA expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decre...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62KQPubMed
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