null
SMILES CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1
InChI Key InChIKey=OFJRNBWSFXEHSA-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 12676
Affinity DataKi: 0.190nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.190nM ΔG°: -13.1kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Binding affinity to human coagulation factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nM ΔG°: -13.1kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nM ΔG°: -13.1kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nM ΔG°: -13.1kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 540nMAssay Description:Inhibition of human factor 2aMore data for this Ligand-Target Pair
Affinity DataKi: 540nM ΔG°: -8.46kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 540nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 540nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: >2.30E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: >2.30E+3nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
Affinity DataKi: >6.30E+3nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
TargetCoagulation factor IX(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataKi: 9.00E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor IX(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataKi: >9.00E+3nMAssay Description:Inhibition of human factor 9aMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nM ΔG°: >-6.75kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataKi: >1.20E+4nMAssay Description:Inhibition of human factor 11aMore data for this Ligand-Target Pair
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataKi: >1.50E+4nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataKi: >1.50E+4nM ΔG°: >-6.51kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor IX(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataKi: >1.50E+4nM ΔG°: >-6.51kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human plasminMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of human activated protein CMore data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human tPAMore data for this Ligand-Target Pair