null

SMILES C[C@H](N)Cn1ccc2cc(F)c(Cl)cc12

InChI Key InChIKey=XJJZQXUGLLXTHO-ZETCQYMHSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50144841   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Binding affinity against human 5-hydroxytryptamine 2C receptor using displacement of [3H]DOBMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q270845QPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8XG5PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]5HT from human 5HT2CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M27PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research Ltd

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  5.10nMAssay Description:Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8XG5PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research Ltd

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]5HT from human 5HT2BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M27PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NKRPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  32nMAssay Description:Binding affinity against human 5-hydroxytryptamine 2A receptor using displacement of [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q270845QPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Displacement of [125I]DOI from human 5HT2AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M27PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometricimaging plate readerMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8XG5PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataKi:  39nMAssay Description:Displacement of [3H]5-HT from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NKRPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  4nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q211BPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research Ltd

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q211BPubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  200nMAssay Description:Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q270845QPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research Ltd

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NKRPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  400nMAssay Description:Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NKRPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  52nMAssay Description:Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NKRPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  50nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q211BPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  18nMAssay Description:Binding to human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M27PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  131nMAssay Description:Binding to human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M27PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research Ltd

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  4.30nMAssay Description:Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometricimaging plate readerMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8XG5PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  18nMAssay Description:Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8XG5PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  131nMAssay Description:Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometricimaging plate readerMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8XG5PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research Ltd

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)copy SMILEScopy InChI
Affinity DataEC50:  4.30nMAssay Description:Binding to human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M27PubMed