null

SMILES C(CN1CCCC1)Oc1ccc2Nc3nccc(n3)-c3cccc(COC\C=C\COCc1c2)c3

InChI Key InChIKey=HWXVIOGONBBTBY-ONEGZZNKSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50210177   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Binding affinity towards rat beta adrenergic receptor from lung membranes.More data for this Ligand-Target Pair
In DepthDetails
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z18W7PubMed
TargetTyrosine-protein kinase JAK2(Mus musculus)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of JAK2 V617F mutant in BAF3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 23nMMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q515ZPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 1.28E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q515ZPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 520nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q515ZPubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q515ZPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Binding affinity towards rat beta adrenergic receptor from lung membranes.More data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Binding affinity towards rat beta adrenergic receptor from heart membranes.More data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Binding affinity towards rat beta adrenergic receptor from lung membranes.More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Binding affinity towards rat beta adrenergic receptor from lung membranes.More data for this Ligand-Target Pair
In DepthDetails
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Binding affinity towards rat beta adrenergic receptor from heart membranes.More data for this Ligand-Target Pair
In DepthDetails
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Binding affinity towards rat beta adrenergic receptor from lung membranes.More data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair