null

SMILES CN(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=UAKWLVYMKBWHMX-RVDMUPIBSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50111603   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of the Holy Ghost

US Patent
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8XX9US Patent
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 794nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HM59P2PubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Protana Inc.

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6QRNPubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of the Holy Ghost

US Patent
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 3.75E+3nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21G0QF8US Patent
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4WHDPubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against chymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4WHDPubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Protana Inc.

Curated by ChEMBL
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)copy SMILEScopy InChI
Affinity DataKd:  1.95E+4nMAssay Description:Equilibrium binding constant for EPH receptor B2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6QRNPubMed