null

SMILES Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1

InChI Key InChIKey=HWGQMRYQVZSGDQ-HZPDHXFCSA-N

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50084621   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKi:  0.580nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKi:  0.850nMAssay Description:Inhibition of human PARP2 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKi:  0.900nMAssay Description:Inhibition of PARP2 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataEC50:  3.20nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 0.5 hrs by fluorescenc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-tagged human full length PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) a...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  1.10nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  3.30nMMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  24nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP4(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  53nMMore data for this Ligand-Target Pair
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  1.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  5.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP12(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PARP1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc.

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35WJRPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataEC50:  2.5nMAssay Description:Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair