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SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12

InChI Key InChIKey=XWAONOGAGZNUSF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50035105   

TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat liver membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32Z9MPubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92XBPubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32Z9MPubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:In vivo inhibitory activity against Angiotensin I converting enzyme was evaluated in renal hypertensive ratsMore data for this Ligand-Target Pair
In DepthDetails
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of purified human kidney thiopurine methyltransferase (TPMT)More data for this Ligand-Target Pair
In DepthDetails
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in quinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32Z9MPubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32Z9MPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Displacement of [3H](+)pentazocine from sigma 1 receptor in rat brain homogenates without cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VSXPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Binding affinity to sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6KRMPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20P11KXPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Binding affinity to sigma-1 opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3T54PubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ92XBPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1M8PPubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
H. Lundbeck A/S

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Binding affinity towards Dopamine receptor D2 binding site using [3H]spiroperidol.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1M8PPubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
H. Lundbeck A/S

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor binding site using [3H]8-OH-DPAT .More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1M8PPubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
H. Lundbeck A/S

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor binding site using [3H]ketanserin .More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1M8PPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Displacement of [3H] (+)-pentazocine from sigma 1 receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2TW8PubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0VKDPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0VKDPubMed