null

SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1

InChI Key InChIKey=OAVGBZOFDPFGPJ-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 33971   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of CYP3A4-catalyzed midazolam 1'-hydroxylation in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VR1PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VR1PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VR1PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VR1PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.10nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X278QPubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PKCeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VR1PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44RQCPubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PKCepsilon (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930WF1PubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PKCeta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930WF1PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of PKCtheta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930WF1PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 81nMAssay Description:Inhibition of PKCtheta in human Jurkat T cells assessed as reduction in anti-CD3/CD28 antibody-induced T-cell activation by measuring decrease in IL-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930WF1PubMed
TargetProtein kinase C beta type(Rattus norvegicus (rat))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 234nMAssay Description:Inhibition of PKCbeta in mouse B cells assessed as reduction in IgM-stimulated cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930WF1PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCbeta1 (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930WF1PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PKCdelta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930WF1PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PKCalpha (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataEC50:  9.70E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JS9ST6PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 0.950nMMore data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3XF8PubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))TBA
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3XF8PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3XF8PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 0.220nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3XF8PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VR1PubMed