null
SMILES CC(C)OC(=O)c1cn(Cc2c(F)cccc2F)c2sc(c(CN(C)Cc3ccccc3)c2c1=O)-c1ccc(NC(=O)C(C)C)cc1
InChI Key InChIKey=RANJJVIMTOIWIN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50067485
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataKi: 60nMAssay Description:Binding affinity of the compound was determined towards rat Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Binding affinity of the compound against gonadotropin-releasing hormone receptor of ratMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Ability of compound to inhibit [I125-Tyr5,DLeu6,NMeLeu7,Pro9-NEt]GnRH agonist binding to the rat Gonadotropin-releasing hormone receptor was evaluate...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Ability of compound to inhibit [I125-Tyr5,DLeu6,NMeLeu7,Pro9-NEt]GnRH agonist binding to the cloned human Gonadotropin-releasing hormone receptor was...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of Rat gonadotropin-releasing hormone receptor(moderate affinity)More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Macaca mulatta)
Neurocrine Biosciences, Inc
Curated by ChEMBL
Neurocrine Biosciences, Inc
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Binding affinity at rat GnRH receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:The Compound was tested for the concentration to inhibit 50% of [125 I ]leuprorelin binding to the cloned human Leutinizing releasing hormone recepto...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:The compound was tested for the concentration to inhibit 50% of [125 I]leuprorelin binding to Leutinizing releasing hormone receptor in the membrane ...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of LHRH-stimulated arachidonic acid (AA) release from CHO cells expressing human Leutinizing releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Tested for antagonist concentration required to inhibit specific binding of [125I]leuprorelin to monkey Leutinizing releasing hormone receptor in clo...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Antagonist concentration required to inhibit specific binding of [125I]leuprorelin to human luteinizing releasing hormone receptor in cloned chinese ...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Tested for antagonist concentration required to inhibit specific binding of [125I]leuprorelin to Leutinizing releasing hormone receptor in rat anteri...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of [125I]leuprorelin binding to rat anterior pituitary LHRH receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of [125I]leuprorelin binding to monkey anterior pituitary LHRH receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:The compound was tested for the concentration to inhibit 50% of [125 I]leuprorelin binding to Leutinizing releasing hormone receptor the membrane fra...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against human GnRH receptor of the compound using des-Gly10[125I-Tyr5, D-Leu, NMeLeu, Pro-NEt]GnRH radioligandMore data for this Ligand-Target Pair