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SMILES Clc1c(CN2CCCC2=N)[nH]c(=O)[nH]c1=O

InChI Key InChIKey=QQHMKNYGKVVGCZ-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 20079   

TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataKi:  1.30nM ΔG°:  -12.6kcal/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibitory activity against thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Escherichia coli)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against thymidine phosphorylase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445N8KPubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Competitive inhibition of human thymidine phosphorylase in presence of thymidineMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human placenta thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human placenta thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of thymidine phosphorylase (unknown origin) using thymidine as substrate after 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human placental thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Escherichia coli)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of Escherichia coli Thymidine phosphorylase by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP05MRPubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Escherichia coli)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of Thymidine phosphorylase from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7VGPPubMed
TargetThymidine phosphorylase(Escherichia coli)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GX4FC3PubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences Inc.

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair