null

SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12

InChI Key InChIKey=RCODMGPJQVRMFZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50004633   

TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-ligand from platelet activating factor (PAF) receptor in rabbit plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M045D5
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataKi:  7.10nMAssay Description:Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9JM7PubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-leukotriene D4 (LTD4) from receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M045D5
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 6.80E+3nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3DX8PubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibitory effect on PAF induced platelets aggregation in rabbitMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PMW
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9QK7
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibitory effect on PAF induced platelets aggregation in rabbitMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PMW
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibitory effect on PAF induced platelets aggregation in rabbitMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PMW
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 6.60E+3nMAssay Description:Displacement of [3H]nitrendipine from L-type calcium channel of bovine frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3DX8PubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3DX8PubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JS9R2XPubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0GSSPubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of bovine frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3DX8PubMed